Description
Date depot: 1 janvier 1900
Titre: Evolution des voies de signalisation impliquées dans les cancers
Directeur de thèse:
Hervé ISAMBERT (PC_Curie)
Domaine scientifique: Sciences et technologies de l'information et de la communication
Thématique CNRS : Non defini
Resumé:
{{Résumé/Abstract}}
The emergence and expansion of complex signal transduction networks by duplication of ancestral signalling genes has enabled the progressive diversification of eukaryotes from 'simple' unicellular species to more complex multicellular organisms. In particular, the ras-superfamily has expanded to reach more than one hundred genes in human, leading to locally distinct yet globally intermingled signaling pathways under intense scrutiny for their implication in numerous cancers. Yet, the evolutionary link between this long time scale expansion of signaling networks and their short term susceptibility to oncogenic mutations remains a mystery. The aim of this PhD project is to investigate the underlying connection between these long and short term evolutionary dynamics, through comparative genomics approach across newly sequenced genomes from higher eukaryotes and complex systems models for systems biology (refs.1-4).
Doctorant.e: Singh Param Priya