Description
Date depot: 5 avril 2018
Titre: Modelling of a Smart Medical Implant in its environment
Directeur de thèse:
Sylvain FERUGLIO (LIP6)
Encadrant :
Julien DENOULET (LIP6)
Domaine scientifique: Sciences et technologies de l'information et de la communication
Thématique CNRS : Non defini
Resumé:
Project
The spinal cord
represents the entrance of the sensory information and the exit of the motor
commands of the limbs and the trunk. Its disease can lead to the paralysis of
at least one limb.
Current
developments in post-traumatic follow-up are mainly focused on non-invasive
imaging techniques (MRI, scanner ...). However, these techniques are not
satisfactory without the use of complementary approaches. As part of this
project, we propose to contribute it by using new technologies.
The project in
which this PhD fits is in the field of engineering applied to biomedical. It
aims to develop a new approach to the chronic imaging of the spinal cord by the
realization of an intelligent implant (biocompatible optoelectronic
telecommunicating embedded system) allowing the monitoring of the functional
state (chronic measurement of the both electro-physiological and metabolic activities)
of the spinal cord [1].
Issues
This biomedical
engineering research project is at the interface of physics, electronics,
signal processing and medicine. The issues are multiple and can be divided into
three main points:
- The first issue
is at the project level in which this realization is integrated, namely the
functional and anatomical implantable imaging and, more particularly, the
detection and the aid to diagnosis and local treatment of spinal cord trauma.
Following previous works, the feasibility of this type of imaging has been
proven [2-7]. It is of real interest to the world of medicine, since the
information obtained was previously inaccessible.
- The second
challenge concerns the realization of the system. The multimodal implant must
be biocompatible, small size, low consumption and telecommunicant, which
requires removing certain technological locks.
- From the
different carried out experiments, the modelling of the global system in its
biological environment is the third issue of this project. It will lead to a
model of this part of the central nervous system and open the door to the
development of tools for:
o Assistance to
doctors and for the in-depth study of the spinal cord;
o For rapid
prototyping of future other embedded devices.
In this context,
this thesis will focus mainly on the last point, namely the multi-physics
modelling of the in development device in its operating environment (the associated
biological environment) [8, 9], in order to estimate the performance of the
heterogeneous system that we want to design and, thus, to help in the choice of
the optimum architecture and the associated components.
At first, we will
focus on the opto-electronic part of the implant. Then, we will focus on the
optical and mechanical parts associated with the biological environment and
their evolution over time, in association with the packaging of the implant.
This will involve the development of an experimental bench for carrying out in
vitro experiments.
Doctorant.e: Li Songlin