Projet de recherche doctoral numero :5174


Date depot: 5 avril 2018
Titre: Modelling of a Smart Medical Implant in its environment
Directeur de thèse: Sylvain FERUGLIO (LIP6)
Encadrant : Julien DENOULET (LIP6)
Domaine scientifique: Sciences et technologies de l'information et de la communication
Thématique CNRS : Non defini

Resumé: Project The spinal cord represents the entrance of the sensory information and the exit of the motor commands of the limbs and the trunk. Its disease can lead to the paralysis of at least one limb. Current developments in post-traumatic follow-up are mainly focused on non-invasive imaging techniques (MRI, scanner ...). However, these techniques are not satisfactory without the use of complementary approaches. As part of this project, we propose to contribute it by using new technologies. The project in which this PhD fits is in the field of engineering applied to biomedical. It aims to develop a new approach to the chronic imaging of the spinal cord by the realization of an intelligent implant (biocompatible optoelectronic telecommunicating embedded system) allowing the monitoring of the functional state (chronic measurement of the both electro-physiological and metabolic activities) of the spinal cord [1].   Issues This biomedical engineering research project is at the interface of physics, electronics, signal processing and medicine. The issues are multiple and can be divided into three main points: - The first issue is at the project level in which this realization is integrated, namely the functional and anatomical implantable imaging and, more particularly, the detection and the aid to diagnosis and local treatment of spinal cord trauma. Following previous works, the feasibility of this type of imaging has been proven [2-7]. It is of real interest to the world of medicine, since the information obtained was previously inaccessible. - The second challenge concerns the realization of the system. The multimodal implant must be biocompatible, small size, low consumption and telecommunicant, which requires removing certain technological locks. - From the different carried out experiments, the modelling of the global system in its biological environment is the third issue of this project. It will lead to a model of this part of the central nervous system and open the door to the development of tools for: o Assistance to doctors and for the in-depth study of the spinal cord; o For rapid prototyping of future other embedded devices. In this context, this thesis will focus mainly on the last point, namely the multi-physics modelling of the in development device in its operating environment (the associated biological environment) [8, 9], in order to estimate the performance of the heterogeneous system that we want to design and, thus, to help in the choice of the optimum architecture and the associated components. At first, we will focus on the opto-electronic part of the implant. Then, we will focus on the optical and mechanical parts associated with the biological environment and their evolution over time, in association with the packaging of the implant. This will involve the development of an experimental bench for carrying out in vitro experiments.

Doctorant.e: Li Songlin